Ruffier can be both a middle name and a surname. Notable people with the surname include:
Jean Ruffier des Aimés (1902–1976), French rower James Ruffier (born 1974), French racing driver Romain Ruffier (born 1989), French football goalkeeper Stéphane Ruffier (born 1986), French football goalkeeper
See also Arboretum Robert Ruffier-Lanche, arboretum on the Université Grenoble Alpes campus Ruffy (disambiguation)