N-Propyltryptamine (NPT) is a serotonin receptor modulator of the tryptamine family related to N-methyltryptamine (NMT). "The normal-propylamine NPT has been made by the oxalylamide route, with the amide having with a mp 179–181 °C (75%) from benzene and NPT hydrochloride mp 186–187 °C (33%) from MeOH/benzene. An attempt to make NPT by the alkyl halide procedure failed. Using these same ratios of reactants, there was the formation of a sizable quantity of DPT with appreciable unreacted tryptamine presence (T:NPT:DPT/1:5:4). A recycling under the same conditions gave T:NPT:DPT/0:3:7) and a third cycle gave only DPT, but with a loss of almost 90% of the material presumably to quaternary salt formation. Interestingly NPT is less toxic than DPT in experimental mice, but has not been assayed yet in man." According to Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved), NPT is not known to have been tested in humans. It acts as a serotonin receptor agonist in the rat uterus and stomach strip, with slightly lower potency than dimethyltryptamine (DMT). However, in contrast to DMT and NMT, NPT did not cause central effects in dogs. It is said to be less toxic than dipropyltryptamine (DPT) in rodents. The chemical synthesis of NPT has been described. NPT was first described in the scientific literature by Speeter and Anthony by 1954. Subsequently, the drug was described by Shulgin in TiHKAL in 1997.
See also Substituted tryptamine
References
External links NPT - Isomer Design N-Alkylated Tryptamines - countyourculture