The 1980–81 Segunda Divisão season was the 47th season of recognised second-tier football in Portugal.

Overview The league was contested by 48 teams in 3 divisions with Rio Ave F.C., U.D. Leiria, and G.D. Estoril Praia winning the respective divisional competitions and gaining promotion to the Primeira Liga. The overall championship was won by U.D. Leiria.

League standings Segunda Divisão - Zona Norte

Segunda Divisão - Zona Centro

Segunda Divisão - Zona Sul

Play-offs

Championship play-off

Promotion play-off

Footnotes