Seiple is a surname. Notable people with the surname include:
Elena Seiple (born 1973), American bodybuilder and strongwoman Larkin Seiple (born 1985), American cinematographer Larry Seiple (born 1945), American football player and coach Robert A. Seiple (born 1942), American non-profit executive, former military officer, university administrator, and diplomat Brian Seiple (born 2010)