2CI-2-EtO, also known as 2-ethoxy-5-methoxy-4-iodophenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-I. "There is one Iodotweetio known. In Scrabble, would you challenge a word that had seven of its eleven letters as vowels? Especially if the vowels were, specifically, iooeeio? It sounds just a little like the noise coming out of Old McDonald’s farm. But a Tweetio there is, namely, the 2-EtO-homologue of 2C-I. This is 2-ethoxy-4-iodo-5-methoxyphenethylamine, or 2CI-2ETO. The hydrochloride salt was a white, crystalline product with a melting point of 175–175.5 °C. The threshold level of activity was seen at an oral dose of 5 milligrams, and the generated effects were completely dispersed in a couple of hours. Most interestingly, larger doses, of up to 50 milligrams orally, seem to produce no more intense an effect, but simply to stretch out this threshold for an additional couple of hours. At no level that has been tried, has 2CI-2ETO produced even a plus-two response." It is the derivative of 2C-I in which the methoxy group at the 2 position has been replaced with an ethoxy group.
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CI-2-EtO's dose is 5 to 50mg orally and its duration is 2 to 4hours. The effects of 2CI-2-EtO have been reported to include threshold effects and no more than a "plus-one" on the Shulgin Rating Scale, with no specific effects having been described. The drug produced threshold effects lasting 2hours at a dose of 5mg orally. A dose of 50mg, or 10-fold higher, produced no more intense of effects and only served to extend its duration to 4hours.
The chemical synthesis of 2CI-2-EtO has been described.
2CI-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.
See also TWEETIO (psychedelics)
References
External links 2CI-2ETO - Isomer Design