6-Ethyl-9-oxaergoline (EOE), also known as N-ethyl-9-oxaergoline, is a dopamine receptor agonist of the 9-oxaergoline family. It is a potent dopamine receptor agonist and produces effects in animals including antiparkinsonian-like effects, stereotypy, hypothermia, hypolocomotion at lower doses and hyperlocomotion at higher doses, and emesis. In addition to its dopaminergic activity, EOE shows agonist and antagonist activities at the α2-adrenergic receptor. It shows weaker affinity for the serotonin 5-HT1 and 5-HT2 receptors as well. EOE was first described in the scientific literature in 1982.
See also Substituted 9-oxaergoline RU-29717 (N-propyl-9-oxaergoline; POE) Voxergolide (RU-41656)
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