9-Oxaergoline is a low-potency dopamine receptor agonist related to the ergolines. It is the analogue and bioisostere of ergoline in which the carbon atom at the 9 position of the ergoline ring system has been replaced with an oxygen atom. A few notable derivatives of 9-oxaergoline have been studied and characterized, including RU-29717 (N-propyl-9-oxaergoline), 6-ethyl-9-oxaergoline (EOE), and voxergolide (RU-41656), which are all substantially more potent as dopamine receptor agonists than 9-oxaergoline itself. Other derivatives, such as N-methyl-9-oxaergoline, have been characterized as well. In addition to its dopaminergic activity, RU-29717 is notable in also having affinity for serotonin receptors and in producing a short-lasting head-twitch response in rodents. The head-twitch response is notable in being a behavioral proxy of psychedelic effects caused by serotonin 5-HT2A receptor agonism. The potential serotonergic activities of 9-oxaergoline and N-methyl-9-oxaergoline do not appear to have been reported.
See also Substituted ergoline Naxagolide
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