Jayalakshmi is a surname and a given name. Notable people with the name include:
Fatafat Jayalakshmi (1958–1980), Indian actress mainly in Tamil and Telugu films K. S. Jayalakshmi, Indian actress who works in the Tamil film and television industries P. K. Jayalakshmi, Indian politician, former Minister for Welfare of Backward Communities in the state Government of Kerala Radha Jayalakshmi, Radha (1932–2025) and Jayalakshmi (1932–2014), Indian Carnatic music vocalist duo S. Jayalakshmi (1920–2007), Indian Tamil-language film actress and singer Soolamangalam Jayalakshmi, one of the Soolamangalam Sisters, Carnatic music sister-pair vocalists and musicians V. Jayalakshmi, Indian politician and former Member of Parliament Valdivel Jayalakshmi (born 1971), Indian sprinter Jayalakshmi Sarikonda (born 1994), Indian archer Jayalakshmi Seethapura, folklorist of modern India who writes in Kannada language
See also Jayalakshmi Vilas Mansion is a heritage building in Mysore