4-Methylephedrine (4-ME), also known as dihydromephedrone (DHMMC) or as β-hydroxy-4-methylmethamphetamine, is a putative stimulant drug of the phenethylamine, amphetamine, and β-hydroxyamphetamine families. It is the β-hydroxy analogue of mephedrone and is a known metabolite of mephedrone. The drug acts as a monoamine reuptake inhibitor and monoamine releasing agent, albeit with relatively low potency and far less than that of mephedrone.
Pharmacology Pharmacodynamics 4-Methylephedrine acts as a monoamine reuptake inhibitor and monoamine releasing agent in vitro, with potency far lower than that of its parent drug mephedrone.
The drug is a weak reuptake inhibitor of norepinephrine, dopamine, and serotonin, with values of 64.98μM, 23.97μM, and 23.53μM for the serotonin, norepinephrine, and dopamine transporters, respectively. The values for individual enantiomers of 4-methylephedrine have also been reported. In addition, data for induction of monoamine release in the HEK293 system have been reported.
+ Compound Ref Dihydromephedrone 23.97 23.53 64.98 Mephedrone 0.77 2.77 7.83 Normephedrone 6.35 5.46 10.61 4-Hydroxymephedrone 2.92 4.85 73.53 Notes: The smaller the value, the more avidly the drug releases the neurotransmitter.
See also Substituted β-hydroxyamphetamine
References
External links 4-Methylephedrine - Isomer Design