Marie-Eugénie is a feminine compound given name which may refer to:
Marie-Eugénie Caps (1892–1931), French Catholic sister who founded the Congregation of the Missionary Sisters of the Holy Spirit or Spiritaines or Spiritan Sisters Marie-Eugénie de Jésus (1817–1898), French Catholic saint, founder of the Religious of the Assumption
See also Marie Eugenie Delle Grazie (1864–1931), Austrian writer Marie Eugénie Gabriel Denizard (1872–1959), French feminist, first woman candidate in a French presidential election Marie Eugenie Le Lay (born 1992), half-French, half-Thai singer, songwriter and actress