Cinobufotenine, also known as bufotenium, bufoteninium, or 5-hydroxy-N,N,N-trimethyltryptaminium, is a quaternary ammonium cation as well as a derivative of 5-hydroxytryptamine, It is the parent compound for bufotenidine. The compound is a powerful stimulant of the parasympathetic ganglia, activates nicotine-sensitive acetylcholine receptors, сinobufotenine is highly active on the ileum. It is contained within the skin of certain toads (Bufo gargarizans).
Bufotenidine, also known as 5-hydroxy-N,N,N-trimethyltryptammonium (5-HTQ) or as cinobufagine, is an indole toxin related to bufotenin, serotonin, and other tryptamines which is found in the venom of a variety of toads. It acts as a selective serotonin 5-HT3 receptor agonist, and has been used in scientific research to study the function of the serotonin 5-HT3 receptor, though this use has been limited by the fact that, as a quaternary amine, it is unable to readily cross the blood-brain-barrier and hence is peripherally selective.
Bufotenium is the quaternary ammonium cation form of bufotenidine, exhibits nicotine-like activity; activates nicotine-sensitive acetylcholine receptors.
Differences Cinobufotenine is similar to bufotenidine in that it does not readily cross the blood-brain barrier and is therefore peripherally selective. Cinobufotenine has very little activity or low affinity at the 5-hydroxytryptamine receptor, possessing less than one thousandth the potency of 5-hydroxytryptamine. and also has a stimulation of cardiac activity, ten times less than the activity of adrenaline chloride, has a low miotic effect and increases the tone of the isolated intestine and uterus.
See also Substituted tryptamine 4-HO-TMT Aeruginascin 2-Methyl-5-HT Chlorophenylbiguanide
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