Mischo is a surname. Notable people with the surname include:
Georges Mischo (born 1974), Luxembourgish politician and former sports teacher Jean Mischo (born 1938–2016), Luxembourgish European judge Luc Mischo (born 1974), Luxembourgish footballer R.J. Mischo (born 1960), American electric blues harmonicist, singer, songwriter, and record producer