Nyangweso is a surname. Notable people with the surname include:
Benjamin Nyangweso, Kenyan football player and coach Denis Nyangweso (born 1978), Ugandan politician Frank Nyangweso (1939–2011), Ugandan boxer Reuben Sechele Nyangweso (born 1961), Kenyan politician Tony Nyangweso, Ugandan rugby player