Ossandón is a surname. Notable people with the surname include:
Agustín Edwards Ossandón (1815–1878), Chilean businessperson, banker, and politician Fabián Ossandón (), Chilean civil engineer and politician Jorge Ossandón (born 1985), Chilean politician Juan José Ossandón (born 1977), Chilean footballer Manuel José Ossandón Lira (born 1987), Chilean lawyer and politician Ximena Ossandón (born 1963), Chilean teacher, businesswoman, and politician