Duché is a surname. Notable people with the surname include:
Jacob Duché Sr. (1708–1788), American colonist, mayor of colonial Philadelphia Jacob Duché (1737–1798), American colonist, chaplain to the Continental Congress Thomas Spence Duché (1763–1790), American painter
See also
Duquette (surname) Gaspard Duché de Vancy (1756–1788), French artist Joseph-François Duché de Vancy (1668–1704), French playwright