American Dad! twenty-second season premiered on Fox on February 22, 2026, marking the show's return to the network following its cancellation by TBS in March 2025. The season features guest appearances from Ming-Na Wen, RuPaul, Chris Pine, Bradley Whitford, Patrick Stump, Jonathan Frakes, Joe Mantegna, Wayne Newton, Kyle MacLachlan, Mary Steenburgen and Ted Danson. The season concluded on September 13, 2026.
The series focuses on the eccentric upper middle class Smith family, consisting of father, husband, CIA agent, and Republican, Stan; his wife and housewife, Francine; their liberal, hippie, college-aged daughter, Hayley-Fischer; their dorky high-school-aged son, Steve; the family's unusual goldfish, Klaus; flamboyant, master of disguise alien, Roger; Jeff Fischer, Hayley Smith's stoner husband who resides with the Smith family; and Roger's ex-tumor son Rogu, who reside in a fictionalized version of Langley, Virginia.
Season twenty-two contains "400?!", the 400th episode of the show.
Voice cast and characters
Regular Seth MacFarlane as Stan Smith, Roger Smith, Greg Corbin Wendy Schaal as Francine Smith Scott Grimes as Steve Smith Rachael MacFarlane as Hayley Smith Dee Bradley Baker as Klaus Heisler, Rogu Jeff Fischer as Jeff Fischer
Supporting characters Patrick Stewart as Avery Bullock Kevin Michael Richardson as Principal Brian Lewis Curtis Armstrong as Schmuley "Snot" Lonstein Daisuke Suzuki as Toshi Yoshida Eddie Kaye Thomas as Barry Robinson Rachel Dratch as Nerfer Nicole Shabtai as Danuta Tenuta Alan Tudyk as Dr. Kalgary Nicole Shabtai as Esther Lonstein Richard Kind as Al Tuttle
Episodes
Production Development On March 21, 2025, TBS announced that they would not order any additional episodes of the series. It was later reported later that day that the show's original network, Fox, was in contract negotiations with the show's producer, 20th Television Animation, for a multiple season renewal. On April 2, 2025, Fox renewed American Dad for a further four seasons.
Casting Francine's adoptive sister Gwen Ling, who was voiced by Uma Thurman in the season twelve episode "Now and Gwen", is now voiced by Ming-Na Wen.
Opening sequence Starting with this season, a new opening sequence would debut. This time, Jeff appears in the living room, Memphis Stormfront replaces Terry Bates, due to Mike Barker's departure from the series in 2013. Additionally, Rogu also appears, and Stan drives a Ford Expedition instead of a Ford Explorer.
Release The season premiered on February 22, 2026, as part of Fox's Animation Domination block, where it airs alongside Bob's Burgers, Universal Basic Guys and Family Guy during the 2025–26 television season. The 400th episode premiered on September 13, 2026.
References