Galeffi is an Italian surname, possibly derived from or . Notable people with the name include:
Carlo Galeffi (1884–1961), Italian operatic baritone Ernesto Galeffi (1917–1986), Italian sculptor Pietro Francesco Galeffi (1770–1837), Italian Roman Catholic cardinal Romano Galeffi (1915–1988), Italian philosopher and art critic
See also Caleffi
References