Clayton is the county seat of St. Louis County, Missouri, and part of Greater St. Louis metropolitan area. The city has a population of 17,512 people as of 2025. The city has 18 high-rises which stand over tall. As of January 2026, the tallest building in Clayton is Centene Plaza C which stands tall.
Cityscape
Tallest buildings
This list ranks completed buildings in Clayton that stand at least 200 ft (61 m) tall as of 2026, based on standard height measurement. This includes spires and architectural details but does not include antenna masts. The “Year” column indicates the year of completion. Buildings tied in height are sorted by year of completion with earlier buildings ranked first, and then alphabetically.
RankName ImageLocationHeightft (m)FloorsYearPurpose Notes 1 Centene Plaza C 28 2020 Office Also known as Centene Plaza Two. Tallest building in Clayton since 2020. Tallest building completed in Clayton in the 2020s. Tallest building in Greater St. Louis outside of St. Louis. Headquarters for Centene Corporation. 2 The Plaza in Clayton Residential Tower 30 2002 Residential Tallest residential building in Clayton. Tallest building in Clayton from 2002 to 2020. Tallest building completed in Clayton in the 2000s. 3 212 South Meramec 27 2017 ResidentialTallest building in Clayton completed in the 2010s. Also known as Two Twelve Clayton. 4 The Sevens Building 24 1969 Office Tallest building in Clayton from 1969 to 2002. Tallest building in Clayton completed in the 1960s. 5 Pierre Laclede Center II 24 1970 OfficeTallest building in Clayton completed in the 1970s. 6 101 South Hanley 19 1986 OfficeAlso known as the Hanley Corporate Tower and Interco Tower. 7 Clayton on the Park 23 2000 Residential 8 Park Tower 24 1966 Residential Tallest building in Clayton from 1966 to 1969.9PNC Center181973OfficeFormerly known as the National City Center and also known as Chromalloy Plaza.10Centene Plaza B172010OfficePart of Centene Corporation's corporate headquarters.11Maryland Walk172006Residential12The Plaza in Clayton Office Tower152002Office13Pierre Laclede Center I161963OfficeTallest building in Clayton from 1963 to 1966.14Merrill Lynch Centre152000Office15Shaw Park Plaza—142001Office16Bemiston Tower—141982Office17Commerce Bank Building151971Office18Jefferson Smurfit Centre—141985Office
Tallest under construction or proposed
Under construction As of 2026, there are no buildings planned to be taller than 200 ft (61 m) that are under construction in Clayton. The most recent building constructed taller than that height is Centene Plaza C, which was completed in 2020.
Proposed As of 2026, there are no approved or proposed buildings planned to be taller than 200 ft (61 m) in Clayton.
Timeline of tallest buildings NameImageYears as tallestHeightft (m)FloorsNotes Pierre Laclede Center I 1963-1966 16 Park Tower 1966–1969 24 The Sevens Building 1969–2002 24 The Plaza in Clayton Residential Tower 2002–2020 30 Centene Plaza C 2020–Present 28
Notes
See also List of tallest buildings in St. Louis List of tallest buildings in Kansas City List of tallest buildings in Missouri References