José Domínguez may refer to:
José Agustín Domínguez y Díaz (1790–1859), Mexican prelate of the Roman Catholic Church José Domínguez Bécquer (1805–1841), Spanish painter José Pantaleón Domínguez (1821–1894), Mexican politician José Domínguez Echenique (1900–1961), Chilean lawyer and conservative politician José Domínguez Rodríguez (1915–1986), Cuban prelate of the Roman Catholic Church José Domínguez Rial (1940–2000), Spanish footballer José Domínguez Abascal (1953–2024), Spanish engineer and politician José Antonio Domínguez (born 1960), Panamanian politician José Dominguez (born 1974), Portuguese footballer and manager José David Domínguez (born 1980), Spanish race walker José Domínguez (baseball) (born 1990), Dominican baseball pitcher