The 2025 Winston-Salem Challenger was a professional tennis tournament played on hardcourts. It was the first edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Winston-Salem, North Carolina, United States between 8 and 14 September 2025.

Singles main-draw entrants Seeds Country Player Rank1 SeedJuan Pablo Ficovich1291Murphy Cassone1802Mitchell Krueger1863Jack Pinnington Jones2224Johannus Monday2325Garrett Johns3056Alex Rybakov3147Patrick Maloney3248 1 Rankings are as of 25 August 2025.

Other entrants The following players received wildcards into the singles main draw: Patrick Maloney Luca Pow Emon van Loben Sels

The following players received entry into the singles main draw using protected rankings: Blaise Bicknell Thai-Son Kwiatkowski Philip Sekulic

The following player received entry into the singles main draw through the College Accelerator programme: Aidan Kim

The following players received entry from the qualifying draw: Gavin Goode Daniel Milavsky James Trotter Quinn Vandecasteele Cooper Williams Edward Winter

Champions Singles

Jack Pinnington Jones def. Trevor Svajda 6–2, 6–2.

Doubles

Andrew Fenty / Noah Schachter def. Juan José Bianchi / Daniel Milavsky 6–4, 6–4.

References