Cephaloleia affinis is a species of beetle of the family Chrysomelidae. It is found in Bolivia, Brazil (Amazonas, Pará, São Paulo), Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname and Venezuela.

Description Adults reach a length of about 9–10.1 mm. They are reddish-yellow.

Biology The hostplant is unknown, but adults have been collected on Ischnosiphon or Monotagna species and Heliconia stricta.

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