Alfonso or Alphonso is a surname derived from the given name, the latter descending from Asturias and Cantabria. It may refer to:
People Alicia Alfonso (born 1963), Uruguayan actress Celestino Alfonso (1916–1944), Spanish republican and volunteer fighter in the French resistance during World War II Equis Alfonso (born c. 1974), known as X-Alfonso, Cuban hip-hop and Afro-rock musician Kristian Alfonso (born 1963), Puerto Rican American soap opera actress Leopold Alphonso (born 1991), Malaysian footballer Michael Alfonso (1965–2007), ring name Mike Awesome, American professional wrestler Ozzie Alfonso (born 1945), Cuban-American TV director and producer Petrus Alphonsi (died after 1116), also known as Peter Alphonso, Spanish physician, writer, astronomer and polemicist Roland Alphonso (1931–1998), Jamaican saxophonist
Ring name Bill Alfonso, ring name of William Matthew Sierra (born 1957), former professional wrestling referee and manager
Fictional characters Oren Pierre Alfonso, in the Japanese TV series Kamen Rider Gaim
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