De las Casas is a Spanish surname, more famously worn by Bartolomé de las Casas (1484–1566), Spanish historian, social reformer and Dominican friar. Other notable people with the surname include:
Alberto de las Casas (died 1544), Catholic church figure Arán de las Casas (born 1989), Venezuelan actor and singer Dianne de Las Casas (1970–2017), Philippine-born American author and storyteller Emmanuel de Las Cases (1766-1842), French noble and writer Francisco de las Casas (1461–1536), 16th-century Spanish conquistador Horacio González de las Casas (1942–2025), Mexican politician José de Urrutia y de las Casas (1739–1803), Spanish captain general and military engineer Juan Bautista de las Casas (d. 1811), 18th-century Tejano revolutionary Julio Jesús de las Casas (born 1945), Venezuelan sports shooter Luis de Las Casas (1745–1800), Spanish Governor of Cuba Luis Felipe de Las Casas Grieve (1916–1988), Peruvian politician and engineer Manuel de las Casas (1940–2014), Spanish architect Mario de las Casas (1905–2002), Peruvian footballer
Fictional characters Yunior de Las Casas, the subject of two short story collections by author Junot Diaz
See also Fray Bartolomé de las Casas, a municipality in the department of Alta Verapaz San Cristóbal de las Casas, a town and municipality located in the state of Chiapas San Cristóbal de las Casas National Airport