Santi or Santí or delli Santi or di Santi is a surname, and may refer to:
Brenden Santi (born 1993), Australian-Italian rugby league footballer Domenico Santi (1621–1694), also known as il Mengazzino, Italian painter Emanuele Santi, Italian economist and political scientist Enrico Mario Santí, Cuban-American writer and scholar Franco Biondi Santi (1922–2013), Italian winemaker Giancarlo Santi (born 1939), Italian film director and screenwriter Giorgio Santi (1746–1822), Italian scientist Giovanni Santi (1435–1494), Italian painter and decorator, father of Raphael Guido Santi (1962–2019), Italian filmmaker, director and producer Giuseppe Santi (1729–1825), Italian painter Jacques Santi (1939–1988), French film producer Jenny Santi (born 1980), Filipino-born author and philanthropy adviser Marco Santi (born 1963), Italian artist, art restorer, businessman and mosaicist Nello Santi (1931–2020), Italian conductor Nicola Delli Santi (1970), Italian equestrian Nicola Rosini Di Santi (born 1959), French sculptor and painter Pietro Santi Bartoli (1615–1700), Italian engraver, draughtsman and painter Raphael or Raffaello Santi or Sanzio, the painter Raphael (1483–1520) Sebastiano Santi (1788–1866), Italian painter Simone Santi (born 1966), Italian volleyball referee Tom Santi (born 1985), American football player
See also De Santi Sante