Francesca Jones won the singles title at the 2025 Palermo Ladies Open, defeating Anouk Koevermans 6-3, 6–2 in the final. It was her second WTA 125 title and came just two weeks after her first at Contrexéville.

Zheng Qinwen was the two-time reigning champion, but did not participate this year.

Seeds

Draw

Finals

Top half

Bottom half

Qualifying Seeds

Qualifiers

Lucky losers

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

References

External links Main draw Qualifying draw