PHENETH-LAD, or PHENETHY-LAD, also known as 6-(β-phenethyl)-6-nor-LSD, is a drug of the lysergamide family related to lysergic acid diethylamide (LSD). "With success in the preparation of the rather stable nor-LSD intermediate, any number of 6-substituted nor-LSD homologues and analogues can be synthesized. [...] Several analogues are in the chemical literature, and some of them have been explored in direct comparison to LSD. Here are a few examples: [...] N-Phenethyl-nor-LSD (PHENETH-LAD). Nothing at 500 μg." It is the derivative of LSD in which the methyl group at the 6 position has been replaced with a phenylethyl moiety.
The drug failed to substitute for LSD in rodent drug discrimination tests, with a maximum of 25 or 50% LSD-appropriate responding at the highest assessed dose. Unlike other 6-substituted lysergamides, PHENETH-LAD was not assessed at the serotonin receptors. According to Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved), PHENETH-LAD produced no effects in humans at a dose of 500μg. He has specified the potentially active dose as being >350μg and its hallucinogenic potency being less than 30% of that of LSD.
PHENETH-LAD was first described in the scientific literature by Andrew Joseph Hoffman of the lab of David E. Nichols at Purdue University in 1985. Its effects in humans were first described by Shulgin by 1994.
See also Substituted lysergamide NBOMe-LAD
References
External links PHENETH-LAD - Isomer Design