Zermeño is a surname of Spanish origin. Notable people with the surname include:
Adrián Zermeño (born 1979), Mexican former professional footballer Andrew Zermeño (born 1935), American cartoonist Cinthia Zermeño Moore, Mexican-born American politician Jorge Zermeño Infante (born 1949), Mexican lawyer and politician Paloma Zermeño (born 1995), American-born Mexican footballer and beach soccer player
See also Ernst Zermelo (1871–1953), German logician and mathematician