NGC 4653 is an intermediate spiral galaxy in the constellation of Virgo. Its velocity with respect to the cosmic microwave background is , which corresponds to a Hubble distance of . However, two non-redshift measurements give a closer distance of . It was discovered by German-British astronomer William Herschel on 11 April 1787.

NGC 4642 Group NGC 4653 is a member of the NGC 4642 Group (also known as LDC 913). This trio of galaxies includes and . A study published in 2022 claims that NGC 4653 and NGC 4642 form a physical pair, separated by about 50 kpc, and that there is a high probability of a merger in the near future.

Supernovae Three supernovae have been observed in NGC 4653: SN 1999gk (TypeII, mag. 15.7) was discovered by Perry Berlind on 15 December 1999. SN 2009ik (TypeIa, mag. 15.3) was discovered by on 22 August 2009. SN 2025mqc (TypeIb, mag. 18.78) was discovered by ATLAS on 31 May 2025.

See also List of NGC objects (4001-5000)

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