Bussche is a German surname. Notable people with the surname include:
Bussche family, an old East-East-Westphalian German noble family Axel von dem Bussche (1919–1993), German officer during World War II Baroness Gösta von dem Bussche-Haddenhausen (1902–1996), German noblewoman and the mother of Prince Claus of the Netherlands. Charles Van Den Bussche (1876–1958), Belgian sailor who competed in the 1920 Summer Olympics Georg Wilhelm von dem Bussche (1726–1794), Hanoverian Army officer and nobleman Hilmar von dem Bussche-Haddenhausen (1867–1939), German nobleman and a diplomat
See also Vandenbussche