2nd Maryland Infantry Regiment may refer to:
2nd Maryland Regiment, a unit during the American Revolution 2nd Maryland Infantry Regiment (Confederate), a regiment in the Confederate States Army 2nd Maryland Infantry Regiment (Union), a regiment in the Union army 2nd Maryland Infantry Regiment, Potomac Home Brigade, a regiment in the Union army 2nd Maryland Infantry, Eastern Shore, a regiment in the Union army
See also 2nd Maryland Cavalry Battalion, a Confederate unit