Rouillé is a French surname, sometimes written Rouille. Notable people with the surname include:
André Rouillé (1948–2025), French historian and theorist of photography Angélique de Rouillé (1756–1840), Belgian writer Antoine Louis Rouillé (1689–1761), French statesman Blandine Rouille (born 1980), French yacht racer Guillaume Rouillé (c. 1504–1589), French bookseller-printer and Renaissance humanist John E. Rouille (1932–2024), American law enforcement officer