R8 or R-8 may refer to:

Transport Audi R8, used from 1999–2006 by Audi for Le Mans 24 Hours race cars, and from 2007–2024 for a street legal car List of Audi R8 automobiles R8 (Rodalies de Catalunya), a commuter rail line bypassing Barcelona, Catalonia, Spain R8 (SEPTA), a commuter rail line in Philadelphia, United States, which has been split into: Chestnut Hill West Line, R8 Chestnut Hill West Fox Chase Line, R8 Fox Chase R8 (RER Vaud), an S-Bahn line in the Swiss canton of Vaud Kyrgyzstan Airlines, from its IATA airline designators Radial Road 8 or R-8, an arterial road of Manila, Philippines Renault 8, a small family car produced in the 1960s and early 1970s R8A (New York City Subway car) Rover R8 platform

Other uses R8, a machine taper originally designed for Bridgeport Milling Machines R8: Contact with combustible material may cause fire, a risk phrase in chemistry HK R8, a modified version of the Heckler & Koch SL8 rifle Smith & Wesson M&P R8, a version of the Smith & Wesson Model 327 revolver HP roman8, an 8-bit character set Kaliningrad K-8, a medium-range air-to-air missile known as R-8 in service Leica R8, a 1996 manual focus 35 mm single-lens reflex camera Canon EOS R8, a mirrorless camera Receptor 8, the eighth in line of a series of cellular receptors, generally at the end of an acronym Roland R-8, a 1988 electronic drum machine , a 1919 United States Navy submarine

See also R08 (disambiguation) 8R (disambiguation)