Cassarino is a Sicilian surname, either derived from the town of Cassaro or from , "box- or case-maker". Notable people with the surname include:

Mathias Gallo Cassarino (born 1992), Italian Muay Thai fighter Primo Cassarino (born 1956), American mobster Stacie Cassarino (born 1975), American poet, educator and editor

See also Cassar Cassarà

References