Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase, known also as cyclic phosphate dihydrolase is a hydrolase enzyme found in various species of bacteria. It uses water to catalyze the hydrolysis of 5-phospho-α-D-ribose cyclic-1,2-phosphate to form D-ribofuranose-5-phosphate via D-ribofuranose-2,5-bisphosphate.
In Eggerthella lenta, Gordonibacter urolithinfaciens and Gordonibacter pamelaeae, the enzyme is encoded by the gene phnPP. The protein consists of 252 amino acids. The enzyme is known to have metal-ion binding sites for Mn2+ and Zn2+. The enzyme is involved in the catabolism of organophosphonates. References