De la Garza is a surname. Notable people with the surname include:

Alana de la Garza (born 1976), American actress Bernardo de la Garza (born 1970), Mexican politician Bianca de la Garza, American journalist and television personality Carlos de la Garza (1807–1882), Tejano rancher and entrepreneur Carlos de la Garza (music producer), 21st century American mixer, record producer, engineer, musician and songwriter Eliseo Arredondo de la Garza (1870–1923), Mexican politician and diplomat Emeterio de la Garza Jr. (1873–1928), Mexican politician and businessman Emilio A. De La Garza (1949–1970), United States Marine Corps lance corporal posthumously awarded the Medal of Honor Gabriela de la Garza (born 1976), Mexican actress Ignacio de la Garza (1905–?), Mexican footballer Jorge Luis de la Garza (born 1981), Mexican politician José Antonio de la Garza (1776–1851?), Tejano who was the first landowner in San Antonio, Texas, and mayor of San Antonio Juan de la Garza (born 1961), Mexican retired javelin thrower Kika de la Garza (1927–2017), American politician and lawyer Lucia and Mila de la Garza, half of The Linda Lindas American rock band and daughters of the music producer Luis de la Garza (born 1954), Mexican-born American television executive, businessman, community leader and convicted bank robber Madison De La Garza (born 2001), American actress and filmmaker Mauricio González de la Garza (1923–1995), Mexican journalist, writer and music composer Mercedes de la Garza (born 1939), Mexican writer, historian, researcher and academic Patricia de la Garza De León (1775–1849), matriarch of one of the prominent founding families of early Texas Rodolfo de la Garza (1942–2018), American political scientist Rosa María de la Garza (born 1960), Mexican anti-human trafficking activist Rosario Ibarra de la Garza (1927–2022), Mexican activist and politician Venustiano Carranza de la Garza (1859–1920), Mexican politician and President of Mexico

See also A. J. DeLaGarza (born 1987), American soccer player who also played internationally for Guam Garza (surname)