Derlis is a given name. Notable people with the name include:
Derlis Alegre (born 1994), Paraguayan footballer Derlis Ayala (born 1990), Paraguayan long-distance runner Derlis Cardozo (born 1981), Paraguayan football defender Derlis David Meza Colli (born 1988), Paraguayan professional footballer Derlis Florentín (1984–2010), Paraguayan football striker Derlis Gómez (born 1972), retired Paraguayan footballer Derlis González (born 1994), Paraguayan professional footballer Derlis González (footballer, born 1978), Paraguayan footballer Derlis Orué (born 1990), Paraguayan professional footballer Derlis Paredes (born 1985), Paraguayan footballer Derlis Soto (born 1973), Paraguayan international footballer