25T4-NBOMe, also known as N-(2-methoxybenzyl)-4-isopropylthio-2,5-dimethoxyphenethylamine, is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-4.
Use and effects 25T4-NBOMe's reported active dose range has been described as 150 to 1,200μg, with a typical dose estimate of 500μg. The route is sublingual administration.
Interactions
Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 2,500 5-HT1B 5-HT1D 5-HT1E 5-HT1F 5-HT2A 1.6 (Ki)1.3–130 ()46% () 5-HT2B (Ki)200 ()27% () 5-HT2C 16 (Ki) () () 5-HT3 5-HT4 5-HT5A 5-HT6 5-HT7 α1A 580 α1B, α1D α2A 260 α2B, α2C β1–β3 D1 4,900 D2 1,700 D3 1,900 D4, D5 H1 5,400 H2–H4 M1–M5 I1 σ1, σ2 1,500–1,600 (Ki) (mouse)120 (Ki) (rat)4,700 () (mouse)1,100 () (rat)>10,000 () (human)33% () (mouse)31% () (rat) 8,100 (Ki)14,000 () () 4,300 (Ki)28,000 () () 6,200 (Ki)58,000 () () Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:
25T4-NBOMe acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors. Its affinities and activities at a variety of other receptors and transporters have also been described.
History 25T4-NBOMe was first described in the scientific literature by at least 2012.
Society and culture Legal status Canada 25T4-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 25-NB 25T-NBOMe 25T2-NBOMe 25T7-NBOMe
References
External links 25T4-NBOMe - Isomer Design The Small & Handy 25T4-NBOMe Thread - Bluelight