M161 or M-161 may refer to:
Maserati Levante, a car also known as Tipo M161 M161 (Cape Town), a road in Cape Town, South Africa Sisu M-161, a Finnish lorry M-161, a piano model by Schirmer & Son M-161, the identifier of the 1966 romance novel Nurse at Moorcroft Manor written by Sharon Heath and published by Ace Books