Dessain is a surname of Normandy origins. Notable people with the surname include:
(1808–1882), French painter (1837–1913), Catholic printer-publisher and politician for the Catholic Party (1871–1944), Belgian printer and politician and son of the above Francis Dessain (1875–1951), Belgian lawyer, priest, and footballer and brother of the above
See also Alexis Dessaint (1847–1890), lawyer and political figure in Quebec