Yitzhaki () is a Hebrew surname. Notable people with the surname include:
Avigdor Yitzhaki (1949–2025), Israeli politician Barak Yitzhaki (born 1984), Israeli former footballer Shlomo Yitzhaki (1944–2023), Israeli economist Uriel Yitzhaki (born 1949), Israeli diplomat Yaakov Yitzhaki (1846–1917), Russian-born rabbi, scholar, religious Zionist
See also Abraham Yizhaki, a 16th-century Greek writer, Talmudic scholar and dayyan Shlomo Yitzchaki, known as Rashi (c. 1040–1105), a French rabbi Meir Itzhaki, a former Israeli footballer Tal Itzhaki (born 1956), an Israeli theatre designer and translator