Settimio is an Italian masculine given name. Notable people with the name include:
Settimio Borsari (died 1594), Italian Roman Catholic bishop Settimio Ferrazzetta (1924–1999), Italian-born Guinea-Bissauan Roman Catholic bishop Settimio Lucci (born 1965), Italian football player and coach Settimio Piacentini (1859–1921), Italian general Settimio Simonini (1913–1986), Italian racing cyclist Settimio Todisco (1924–2025), Italian Roman Catholic archbishop
See also Settimia Caccini (1591–c. 1638), Italian soprano and composer Septimius (usurper) (in Italian: Settimio), 3rd-century Roman usurper