FLY is a family of phenethylamine and benzofuran psychedelics possessing a benzodifuran or similar ring system. The FLY drugs were so-named because of the resemblance of their chemical structures to flying insects like dragonflies and butterflies. They are analogues of 2,5-dimethoxyphenethylamines in which the 2- and 5-position methoxy groups have been cyclized into furan and/or tetrahydrofuran rings. They may be 2C, DOx, 25-NB, or other FLY versions of psychedelic phenethylamines.
Examples of different types of FLY drugs, in the case of the base psychedelic 2C-B, include 2C-B-FLY, 2C-B-DragonFLY, and 2C-B-ButterFLY, among others. BromoDragonFLY (DOB-DragonFLY) is known for its very high potency and its toxicity in overdose. 2C-B-FLY was Ann Shulgin's favorite psychedelic.
Several of the FLY drugs have been shown to act as potent serotonin 5-HT2 receptor agonists.
Use and effects According to Alexander Shulgin, active doses or dose ranges of FLY drugs are 2.5 to 10mg orally for 2C-B-FLY, 1mg orally for DOB-FLY, and 100μg intramuscularly for Bromo-DragonFLY. Other sources provide dose ranges of 0.2 to 0.8mg orally for Bromo-DragonFLY, 1mg orally for DOB-FLY, and 10 to 20mg for 2C-B-FLY. For comparison, 2C-B has a dose range of 12 to 24mg orally while DOB has a dose range of 1 to 3mg orally.
+ Compound Dose Duration 2C-B-FLY 2.5–10 mg or 10–20 mg (2–25 mg+) Unknown DOB-FLY 1 mg Unknown Bromo-DragonFLY 0.2–0.8 mg (0.2–1 mg+) 12–24 hoursa Footnotes: a Bromo-DragonFLY can have a delayed onset of up to 6hours and can have a duration of up to 2 to 3days in some cases. Refs: Individual:
Interactions
History The FLY drugs were first described in the scientific literature by Aaron Phillip Monte and David E. Nichols and colleagues at Purdue University by 1995.
List of FLY drugs
2C FLY drugs 2C-B-FLY 2C-B-ButterFLY (2C-B-MOTH) 2C-B-DragonFLY (2C-B-DFLY) 2C-B-5-hemiFLY 2C-C-FLY 2C-I-FLY 2C-DFLY (2C-H-DragonFLY; 2C-H-DFLY) 2C-D-FLY 2C-E-FLY 2C-EF-FLY 2C-T-7-FLY
DOx FLY drugs Bromo-DragonFLY (DOB-Dragonfly; DOB-DFLY) DOB-ANTH DOB-FLY (3C-B-FLY) DOB-2-DragonFLY-5-ButterFLY DOB-5-hemiFLY (bromo-semi-FLY; B-SF) DOB-ButterFLY (DOB-MOTH) DOH-5-hemiFLY (semi-FLY; SF) DOI-2-hemiFLY DOM-FLY DOMOM-FLY DragonFLY (DFLY; DOH-FLY) FLY (DOH-FLY) TFMFly (TFM-FLY; DOTFM-FLY)
25-NB FLY drugs 2C-B-Fly-NBOMe (NBOMe-2CB-Fly) 2C-B-DragonFLY-NBOH 2C-B-FLY-NB2EtO5Cl
Cyclized FLY drugs 2C-B-5-hemiFLY-α6 (BNAP) 2CB7 (2C-B-5-hemiFLY-β7)
Other FLY drugs Diaza-2C-DFLY Hemi-flyscaline (mescaline-hemiFLY) Mescaline-FLY (flyscaline)
Related compounds 9-Aminomethyl-9,10-dihydroanthracene (AMDA) F (F-1; 5-methoxy-6-APDB)
See also Substituted phenethylamine Substituted amphetamine Substituted benzofuran Substituted methoxyphenethylamine 2C, DOx, 4C, 25-NB, scaline, 3C PiHKAL (Phenethylamines I Have Known and Loved) The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds
References
External links "FLY" - Isomer Design