Manuel Ruiz may refer to:
Manuel Antonio Ruíz de la Rosa (born 1965), Dominican Republic Roman Catholic bishop Manuel Ruiz Guerrero (1864–1917), Spanish painter and illustrator Manuel Ruiz de Lopera (1944–2024), Spanish businessman, owner of football club Real Betis Manuel Ruiz Pérez (born 1962), Spanish football goalkeeper and manager Manuel Ruiz Sosa (1937–2009), Spanish football midfielder and manager Manuel Ruiz Urriés de Castilla (1734–1812), Spanish colonial official in the Viceroyalty of Peru Manuel Ruiz Valledor (), Chilean politician Manuel Ruiz Zorrilla (1833–1895), Spanish politician, two-time prime minister in the 1870s
(1888–1936), Spanish physician and politician, executed by Francoist Spain Manuel Ruiz López (died 1860), Roman Catholic saint, one of the 11 Martyrs of Damascus Manuel Ruiz, 19th-century Mexican politician, served two terms at the Secretariat of the Interior Manuel Ruiz, 19th-century Mexican politician, served two terms as governor of Tamaulipas