N-Isopropyltryptamine (NiPT) is a serotonin receptor agonist of the tryptamine family.
Use and effects According to Alexander Shulgin, no active dose level of NiPT has yet been found in humans.
Pharmacology Pharmacodynamics NiPT acts as a potent full agonist of the serotonin 5-HT2A receptor, whereas it is inactive as an agonist of the serotonin 5-HT1A receptor. The drug is also a weak serotonin reuptake inhibitor.
Chemistry Analogues Analogues of NiPT include N-methyltryptamine (NET), N-ethyltryptamine, N-sec-butyltryptamine (NsBT), N-tert-butyltryptamine (NtBT), and diisopropyltryptamine (DiPT), among others.
Derivatives Some derivatives of NiPT include 4-HO-NiPT, 5-HO-NiPT, and 5-MeO-NiPT, among others. 5-MeO-NiPT is likewise a serotonin receptor agonist. It is a potent full agonist or high-efficacy partial agonist of the serotonin 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C receptors. In contrast to 5-MeO-NMT and 5-MeO-NET, which are inactive in the test, 5-MeO-NiPT induces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and hence may be hallucinogenic in humans. 4-HO-NiPT is also a serotonin receptor agonist and produces the head-twitch response in rodents as well.
Society and culture Legal status Canada NiPT is not a controlled substance in Canada as of 2025.
See also Substituted tryptamine
References
External links NIPT - Isomer Design NIPT - TiHKAL - Erowid NIPT - TiHKAL - Isomer Design