Al-Mukhaini () is an Arabic surname, commonly used in Oman. Notable people with the surname include:
Abdul Salam Al-Mukhaini (1988–2025), Omani footballer Abdullah Al-Mukhaini (born 1986), Omani footballer Ahmed Al-Mukhaini (born 1985), Omani footballer Ahmed Hadid Al-Mukhaini (born 1984), Omani footballer Ibrahim Al-Mukhaini (footballer, born 1987) (born 1987), Omani footballer Ibrahim Al-Mukhaini (footballer, born 1997) (born 1997), Omani footballer Mohammed Al-Mukhaini (born 1982), Omani footballer Osama Hadid Al-Mukhaini (born 1987), Omani footballer Saad Al-Mukhaini (born 1987), Omani footballer Yaqoob Juma Al-Mukhaini (born 1982), Omani footballer