DeSanto or Desanto is a surname, commonly used in English-speaking countries. Notable people with the surname include:
Austin DeSanto (born 1998), American wrestler Daniel DeSanto, Canadian actor Karen DeSanto (born 1964), American educator, Democratic politician, and former entertainer Michael Desanto (born 1953), Australian Paralympic athlete Sugar Pie DeSanto (1935–2024), American R&B singer and dancer Tom DeSanto (born 1968), American film producer and screenwriter
See also DeSanto-Shinawi syndrome, a rare genetic disorder