Dehon can be both a surname and a middle name. Notable people with this name include:
As a middle name Arthur Dehon Little (1863–1935), American chemist and chemical engineer
As a surname Jean-Philippe Dehon (born 1956), French football player Léon Dehon (1843–1925), French Catholic priest Nicolas Dehon (born 1968), French football player Theodore Dehon (1776–1817), American bishop