The Kazakh–Uzbek War was a conflict in the first half of the 16th century between the Kazakh Khanate and the Khanate of Bukhara, where the Kazakhs fought over the control of Tashkent and succeeded in 1534.

Since the 1520s, the first internecine war for the throne has been going on in the Kazakh khanate. Long before that, Kasym Khan annexed the lands of the Nogai Horde during the Kazakh–Nogai War, but after his death, the Nogais, as Trepavlov writes, began the Nogai "reconquista" by reconquering their lands and the capital, driving the Kazakhs beyond the Irtysh. But already in 1530, the Kazakhs were able to defeat the Nogais across the Emba River.

The struggle between the Kazakh rulers and the Shaybanids continued even after Tahir Khan left the historical scene, as the Kazakhs posed a real threat to the northern territories of the Uzbek state.

In September of 1536, a letter from the Russian ambassador D. Gubin was delivered to Moscow, stated as; In 1537, Uzbeks, Moghuls, and Nogais defeated the Kazakhs in Battle of San Tash, which killed 37 Kazakh sultans. It was stated as:

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