Pirotte is a Belgian surname. Notable people with the surname include:
Gaspard Pirotte, Belgian gymnast Gautier Pirotte (born 1973), Belgian sociologist Jean-Claude Pirotte (1939–2014), Belgian writer, painter and poet Julia Pirotte (1907–2000), Polish photojournalist Nestor Pirotte (1933–2000), Belgian serial killer Roger Pirotte (1910–?), Belgian cyclist