Hof van Busleyden (; ), also called the Busleyden Palace, is a palace in the municipality of Mechelen in the province of Antwerp in the Flemish Region of Belgium.

History In 1494, François de Busleyden purchased the land for the Hof van Busleyden in Mechelen.Messager des sciences historiques, ou archives des arts et de la bibliographie de Belgique: 1876. (1876). (n.p.): Vanderhaeghen. In 1496, the city granted him land adjoined to his residence in recognition of his services.Bulletin des Commissions Royales d'Art et d'Archéologie. (1875). Belgium: (n.p.). Upon François's death in 1502, his estate was inherited by his three brothers. His brother Hieronymus van Busleyden commissioned architect Rombout II Keldermans who carried out the plan's for the construction beginning in 1503 and ending in 1507.

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